IDH & 1p/19q MRS Classifier
Upload LCModel outputs (.COORD / .PRINT) and view predictions + explanations.
Research Prototype (Not for Clinical Use)
This classifier is a prototype developed from research/clinical data. It is intended for research and educational purposes only.
It must not be used as a clinical diagnosis tool. Clinical use would require appropriate prospective clinical validation (e.g., clinical trials) and regulatory evaluation.
When used responsibly, it may help support non-invasive molecular status prediction alongside ground-truth histopathological / molecular analysis.
This is an early step toward potential clinical translation and is expected to improve as it is trained and validated on larger datasets over time. If you would like to collaborate (e.g., contribute glioma MEGA-PRESS MRS data) or need support for molecular detection from MRS, please contact the team maintaining this website.
LCModel file requirements
These LCModel output files can be obtained by running the MEGA-PRESS processing pipeline available on this website.
If you want to use your own LCModel-processed data, your basis-set must include the following fitted metabolites for the classifier to work.
IDH prediction
Non edited metabolites:
- 2HG
- Glutathione
- Glutamate + Glutamine
- Alanine
- Glutamate
- Betaine
- Glycine
- GABA
- Glutamine
- Lip13a+Lip13b+Lip0+MM09
- Lip20
- syo-inositol
Edited metabolites:
- 2-Hydroxyglutarate
- CRLB 2-Hydroxyglutarate
- GABA
1p/19q codeletion prediction (in addition to IDH)
Non edited metabolites:
- Cystathionine
- Macromolecules
- Total Choline
- Citrate
- Glucose
- myo-inositol
- Lip13a+Lip13b+Lip0+MM09
Edited metabolites:
- Cystathionine
- CRLB Cystathionine
- CRLB 2-Hydroxyglutarate